
This ‘BRCA information hub’ provides informative videos on topics relevant to anyone interested in BRCA or who is a BRCA carrier.
- Between 6-19% of cancers are familial, meaning there is a strong history of cancer in a family. Some types of cancer are more strongly familial than others - breast, colon, thyroid and ovarian. Having a family history may increase you risk of breast cancer by 20-30%
- Around 6-8% of cancer’s are linked to faulty genetics/genes
-The two most common faulty genes linked to breast cancer are called BRCA 1 and BRCA 2. The faulty BRCA gene can be inherited from either the maternal or paternal side of the family
- Carrying a faulty BRCA gene can increase a person’s risk of developing cancer:
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BRCA 1 gene – up to 88% risk of developing breast cancer and a 40-60% risk of developing ovarian cancer
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BRCA 2 - 86% risk of developing breast cancer and 20-30% risk of ovarian cancer
- Pancreatic cancer is also linked to BRCA 1/2
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BRCA 2 - 20% risk of men developing prostate cancer, and 9% risk of male breast cancer
- These faulty BRCA genes have a 50% chance of being passed on to children of a carrier, male or female.
- Around 559 women in Northern Ireland have been tested positive for the BRCA 1 or 2 gene
- Preventative surgery can be an option for women who carry the BRCA 1 or 2 gene
- Other genes linked to a high risk of breast cancer include: TP53, PALB2 and PTEN
(This information has been derived from Prof Morrison, Consultant in Genetic medicine, Belfast City Hospital and his genetics team)
Examples of topics included within the video are:
- BRCA gene – terminology explained
- What is cancer
- Genetic testing
- Screening for BRCA carriers
- Referral for genetic testing self referral – email [email protected]
Examples of topics included within the video are:
– Cancer risks associated with male BRCA carriers
– PSA testing
– Current research relating to prostate cancer
– Annual MRI breasts for ladies aged 30-40, MRI/mammography for age 40-50 yrs
– No screening test for ovarian – current research being carried out to identify a blood test for ovarian
– CA125 blood test not suitable for pre-menopausal women as it is not cancer specific and CA125 can be raised during ovulation, infection etc. Useful blood test for surveillance for ovarian cancer patients (post menopausal) and check if treatment is working.
– Prostate – PSA testing from 40+ for BRCA 2 men and from 50+ if the father has prostate cancer (or 10yrs younger than the father’s age at diagnosis).
Examples of topics included within the video are:
– Menopause explained
– Implications of premature menopause
– Indications for HRT, bone health, menopause and sexual functioning
– Types of HRT and side effects
Research has shown that in general, exercising regularly and eating a healthy diet can lower your risk of developing cancer. Thirty minutes of daily physical exercise can reduce your risk of breast cancer by at least 20%. Carrying excess weight can increase your risk of cancer – having a body mass index of over 30 increases your risk by 25%
Examples of topics included within the video are:
– Impact of smoking, physical activity, alcohol, weight/ diet on cancer risk
Examples of topics included within the video are:
– Overview of ovarian cancer
– Risk factors for BRCA carriers
– Risk reducing surgery and strategies
– Future developments
This talk given by Dr Joanne McManus, Consultant Gynaecologist & Specialist in Reproductive Medicine, outlines a range of options for treating early/premature menopause caused by surgical removal of the ovaries.
This talk given by Mr Chris Hoo, Oncoplastic Breast Surgeon and Mr Gareth Irwin, Consultant Surgeon, outlines the options available for BRCA carriers for preventative breast surgery and reconstruction.
This talk given by Dr Laura Feeney, Medical Oncology Consultant and Clinical Lecturer, outlines ongoing research into blood testing for ovarian cancer
- Speak to your GP who will ask about your family history of cancer and where appropriate refer you to the Family history clinic in the hospital. Once you have been assessed there, then if appropriate you will be referred to the Genetics team.
- The Family History team can make a referral to genetics if they think this is appropriate.
- If a family member has already been assessed by the Genetics team, and if a mutation has been identified, you may be eligible for a predictive test. Patients in this group can self-refer, following the guidance on our website.
- Sometimes a patient may not be eligible for genetic testing or sometimes further genetic testing can be helpful at some point in the future. For this reason, it is always important to go back to the Genetics team if your personal history, or family history, of cancer changes. The genetics team can be contacted by email at [email protected]
- At present, there is no effective screening for pancreatic cancer but all patients should be symptom aware. Research in this area is on-going, and, for patients with a personal or family history of pancreatic cancer, the Genetic team may consider referral to the Europac Study - EUROPAC Researching Hereditary Pancreatic Diseases
- Symptoms of Pancreatic cancer include: o Yellowing of the skin or eyes o Pain on eating / fullness o Upper abdominal pain o Mid-back pain - can radiate to stomach o Indigestion not responding to prescribed medicine o Pale and smelly stools that don’t flush easily o Fatigue o Diabetes - new onset not associated with weight gain o Unexplained weight loss and loss of appetite o Low mood or depression For more information go to: https://www.nipanc.org/
-See the video on breast surgical and reconstruction options for a full description https://actioncancer.org/info-hub/brca/
- Implants in theory should last for life. Sometimes however they need replaced due to a range of factors including significant weight gain, if they become encapsulated etc.
- The benefits of having breast reconstruction using implants is that it is a simpler, shorter operation with shorter recovery times. There is less scarring on the breast and no other operation/scarring needed elsewhere on the body.
- Risks with implants include: infection, wounds not healing properly, the body rejecting the implants forming a capsule /scar tissue around the implant. For more information go to https://www.macmillan.org.uk/cancer-information-and-support/breast-cancer/breast-reconstruction-using-implants
- o https://www.cancer.gov/types/breast/risk-reducing-surgery-fact-sheet
- o https://www.macmillan.org.uk/cancer-information-and-support/worried-about-cancer/causes-and-risk-factors/risk-reducing-breast-surgery
- With BRCA 1 there is up to a 50% risk of getting fallopian tube /ovarian cancer. With BRCA 2 there is up to a 25% risk of fallopian tube / ovarian cancer.
- With Lynch syndrome/MSH2 there is up to a 40% risk (risk is cumulative with age)
- There is currently no screening for fallopian tube/ovarian cancer
- • treat applicants fairly and not require or pressure any applicant to undertake a predictive or diagnostic genetic test
- • not ask for, or take into account the result of a predictive genetic test, except when the life insurance is over £500,000
- • not ask for, or take into account, the result of any predictive genetic test obtained through scientific research
- In addition, ABI has information on their website regarding the Code on genetic testing and insurance https://www.abi.org.uk/data-and-resources/tools-and-resources/genetics/code-on-genetic-testing-and-insurance/